Seminomatous Extragonadal Germ Cell Tumor with Complete Obstruction of the Superior Vena Cava Responding to Intensive Chemotherapy

A 20-year-old man was admitted to our hospital with persistent cough and dyspnea. He had bilateral distention of the jugular veins, and swollen lymph nodes were palpable in the right subclavicular region. Plain X-ray and computed tomography (CT) of the chest showed a solid soft tissue mass in the up...

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Main Authors:	Moritoki, Yoshinobu, Kato, Toshiki, Nishio, Hidenori, Kamisawa, Hideyuki, Hirose, Yasuhiko, Ando, Ryosuke, Akita, Hidetoshi, Okamura, Takehiko
Format:	Online
Language:	English
Published:	The Japanese Association of Rural Medicine 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309346/

id	pubmed-4309346
recordtype	oai_dc
spelling	pubmed-43093462015-02-03 Seminomatous Extragonadal Germ Cell Tumor with Complete Obstruction of the Superior Vena Cava Responding to Intensive Chemotherapy Moritoki, Yoshinobu Kato, Toshiki Nishio, Hidenori Kamisawa, Hideyuki Hirose, Yasuhiko Ando, Ryosuke Akita, Hidetoshi Okamura, Takehiko Case Report A 20-year-old man was admitted to our hospital with persistent cough and dyspnea. He had bilateral distention of the jugular veins, and swollen lymph nodes were palpable in the right subclavicular region. Plain X-ray and computed tomography (CT) of the chest showed a solid soft tissue mass in the upper mediastinum, with leftward displacement of the trachea and complete obstruction of the superior vena cava. Mediastinal radiotherapy (1.8 Gy/day) and methylprednisolone (100 mg/day) were started immediately. Biopsy of the right subclavicular lymph nodes revealed metastatic seminoma. The patient was referred for chemotherapy, which was performed with a combination of cisplatin, bleomycin and etoposide (BEP). A partial response was observed after completion of 3 cycles of chemotherapy, but there was no further tumor shrinkage after additional salvage chemotherapy. The patient is being followed up on an outpatient basis and has been free of recurrence for 32 months after intensive treatment. The Japanese Association of Rural Medicine 2011-07-15 2011 /pmc/articles/PMC4309346/ /pubmed/25648048 http://dx.doi.org/10.2185/jrm.6.32 Text en ©2011 The Japanese Association of Rural Medicine http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Moritoki, Yoshinobu Kato, Toshiki Nishio, Hidenori Kamisawa, Hideyuki Hirose, Yasuhiko Ando, Ryosuke Akita, Hidetoshi Okamura, Takehiko
spellingShingle	Moritoki, Yoshinobu Kato, Toshiki Nishio, Hidenori Kamisawa, Hideyuki Hirose, Yasuhiko Ando, Ryosuke Akita, Hidetoshi Okamura, Takehiko Seminomatous Extragonadal Germ Cell Tumor with Complete Obstruction of the Superior Vena Cava Responding to Intensive Chemotherapy
author_facet	Moritoki, Yoshinobu Kato, Toshiki Nishio, Hidenori Kamisawa, Hideyuki Hirose, Yasuhiko Ando, Ryosuke Akita, Hidetoshi Okamura, Takehiko
author_sort	Moritoki, Yoshinobu
title	Seminomatous Extragonadal Germ Cell Tumor with Complete Obstruction of the Superior Vena Cava Responding to Intensive Chemotherapy
title_short	Seminomatous Extragonadal Germ Cell Tumor with Complete Obstruction of the Superior Vena Cava Responding to Intensive Chemotherapy
title_full	Seminomatous Extragonadal Germ Cell Tumor with Complete Obstruction of the Superior Vena Cava Responding to Intensive Chemotherapy
title_fullStr	Seminomatous Extragonadal Germ Cell Tumor with Complete Obstruction of the Superior Vena Cava Responding to Intensive Chemotherapy
title_full_unstemmed	Seminomatous Extragonadal Germ Cell Tumor with Complete Obstruction of the Superior Vena Cava Responding to Intensive Chemotherapy
title_sort	seminomatous extragonadal germ cell tumor with complete obstruction of the superior vena cava responding to intensive chemotherapy
description	A 20-year-old man was admitted to our hospital with persistent cough and dyspnea. He had bilateral distention of the jugular veins, and swollen lymph nodes were palpable in the right subclavicular region. Plain X-ray and computed tomography (CT) of the chest showed a solid soft tissue mass in the upper mediastinum, with leftward displacement of the trachea and complete obstruction of the superior vena cava. Mediastinal radiotherapy (1.8 Gy/day) and methylprednisolone (100 mg/day) were started immediately. Biopsy of the right subclavicular lymph nodes revealed metastatic seminoma. The patient was referred for chemotherapy, which was performed with a combination of cisplatin, bleomycin and etoposide (BEP). A partial response was observed after completion of 3 cycles of chemotherapy, but there was no further tumor shrinkage after additional salvage chemotherapy. The patient is being followed up on an outpatient basis and has been free of recurrence for 32 months after intensive treatment.
publisher	The Japanese Association of Rural Medicine
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309346/
_version_	1613181608635924480

Seminomatous Extragonadal Germ Cell Tumor with Complete Obstruction of the Superior Vena Cava Responding to Intensive Chemotherapy

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