Reduced 5-Methylcytosine Level as a Potential Progression Predictor in Patients with T1 or Non-Invasive Urothelial Carcinoma

This study aims to elucidate the level of DNA methylation in urothelial carcinomas (UCs) using 5-methylcytosine (5-MeC) immunohistochemistry (IHC). We examined the relationship among 5-MeC levels, DNA (cytosine-5)-methyltransferase 1 (DNMT1) immunostaining levels, and clinicopathologic features. Tis...

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Main Authors: Chung, Chi-Jung, Chang, Chao-Hsiang, Chuu, Chih-Pin, Yang, Chi-Rei, Chang, Yi-Huei, Huang, Chi-Ping, Chen, Wen-Chi, Chung, Mu-Chi, Chang, Han
Format: Online
Language:English
Published: MDPI 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307268/