tRNAs as Antibiotic Targets
Transfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple sta...
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| Format: | Online |
| Language: | English |
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MDPI
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307249/ |
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pubmed-4307249 |
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pubmed-43072492015-02-02 tRNAs as Antibiotic Targets Chopra, Shaileja Reader, John Review Transfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome. Finally, the role of deacylated tRNAs in the bacterial “stringent response” mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed. MDPI 2014-12-25 /pmc/articles/PMC4307249/ /pubmed/25547494 http://dx.doi.org/10.3390/ijms16010321 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Chopra, Shaileja Reader, John |
| spellingShingle |
Chopra, Shaileja Reader, John tRNAs as Antibiotic Targets |
| author_facet |
Chopra, Shaileja Reader, John |
| author_sort |
Chopra, Shaileja |
| title |
tRNAs as Antibiotic Targets |
| title_short |
tRNAs as Antibiotic Targets |
| title_full |
tRNAs as Antibiotic Targets |
| title_fullStr |
tRNAs as Antibiotic Targets |
| title_full_unstemmed |
tRNAs as Antibiotic Targets |
| title_sort |
trnas as antibiotic targets |
| description |
Transfer RNAs (tRNAs) are central players in the protein translation machinery and as such are prominent targets for a large number of natural and synthetic antibiotics. This review focuses on the role of tRNAs in bacterial antibiosis. We will discuss examples of antibiotics that target multiple stages in tRNA biology from tRNA biogenesis and modification, mature tRNAs, aminoacylation of tRNA as well as prevention of proper tRNA function by small molecules binding to the ribosome. Finally, the role of deacylated tRNAs in the bacterial “stringent response” mechanism that can lead to bacteria displaying antibiotic persistence phenotypes will be discussed. |
| publisher |
MDPI |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307249/ |
| _version_ |
1613180997143101440 |