Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge

Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15–20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in so...

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Main Authors:	Ocampo-Garza, Jorge, Herz-Ruelas, Maira Elizabeth, González-Lopez, Elias Eugenio, Mendoza-Oviedo, Eric Eduardo, Garza-Chapa, Juana Irma, Ocampo-Garza, Sonia Sofía, Vázquez-Herrera, Norma Elizabeth, Miranda-Maldonado, Ivett, Ocampo-Candiani, Jorge
Format:	Online
Language:	English
Published:	S. Karger AG 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307011/

id	pubmed-4307011
recordtype	oai_dc
spelling	pubmed-43070112015-02-13 Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge Ocampo-Garza, Jorge Herz-Ruelas, Maira Elizabeth González-Lopez, Elias Eugenio Mendoza-Oviedo, Eric Eduardo Garza-Chapa, Juana Irma Ocampo-Garza, Sonia Sofía Vázquez-Herrera, Norma Elizabeth Miranda-Maldonado, Ivett Ocampo-Candiani, Jorge Published online: December, 2014 Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15–20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in some cases it has been associated with infection, allergic reaction or drug exposure. The majority of patients are diagnosed in an advanced stage and anthracycline based regimen is considered the first-line therapy. Skin involvement is not well characterized, occurring in up to 50% of patients and presenting as nonspecific rash, macules, papules, petechiae, purpura, nodules and urticaria. We present the illustrative case of a 55-year-old woman with an AITL who presented prominent skin findings, arthritis, lymphadenopathy and hypereosinophilia. Skin biopsy reported a T-cell lymphoma and the diagnosis of AITL was confirmed by an axillary lymph node biopsy, which was also positive for Epstein-Barr virus. Chemotherapy with CHOP-21 and thalidomide was given, accomplishing complete remission after six cycles. S. Karger AG 2014-12-17 /pmc/articles/PMC4307011/ /pubmed/25685133 http://dx.doi.org/10.1159/000370302 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ocampo-Garza, Jorge Herz-Ruelas, Maira Elizabeth González-Lopez, Elias Eugenio Mendoza-Oviedo, Eric Eduardo Garza-Chapa, Juana Irma Ocampo-Garza, Sonia Sofía Vázquez-Herrera, Norma Elizabeth Miranda-Maldonado, Ivett Ocampo-Candiani, Jorge
spellingShingle	Ocampo-Garza, Jorge Herz-Ruelas, Maira Elizabeth González-Lopez, Elias Eugenio Mendoza-Oviedo, Eric Eduardo Garza-Chapa, Juana Irma Ocampo-Garza, Sonia Sofía Vázquez-Herrera, Norma Elizabeth Miranda-Maldonado, Ivett Ocampo-Candiani, Jorge Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge
author_facet	Ocampo-Garza, Jorge Herz-Ruelas, Maira Elizabeth González-Lopez, Elias Eugenio Mendoza-Oviedo, Eric Eduardo Garza-Chapa, Juana Irma Ocampo-Garza, Sonia Sofía Vázquez-Herrera, Norma Elizabeth Miranda-Maldonado, Ivett Ocampo-Candiani, Jorge
author_sort	Ocampo-Garza, Jorge
title	Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge
title_short	Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge
title_full	Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge
title_fullStr	Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge
title_full_unstemmed	Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge
title_sort	angioimmunoblastic t-cell lymphoma: a diagnostic challenge
description	Angioimmunoblastic T-cell lymphoma (AITL) accounts for 15–20% of all peripheral T-cell lymphomas. It is a rare subtype of CD4 T-cell peripheral lymphoma that affects aged individuals, causing B symptoms, generalized lymphadenopathy and hepatosplenomegaly. Its pathogenesis is still unclear, but in some cases it has been associated with infection, allergic reaction or drug exposure. The majority of patients are diagnosed in an advanced stage and anthracycline based regimen is considered the first-line therapy. Skin involvement is not well characterized, occurring in up to 50% of patients and presenting as nonspecific rash, macules, papules, petechiae, purpura, nodules and urticaria. We present the illustrative case of a 55-year-old woman with an AITL who presented prominent skin findings, arthritis, lymphadenopathy and hypereosinophilia. Skin biopsy reported a T-cell lymphoma and the diagnosis of AITL was confirmed by an axillary lymph node biopsy, which was also positive for Epstein-Barr virus. Chemotherapy with CHOP-21 and thalidomide was given, accomplishing complete remission after six cycles.
publisher	S. Karger AG
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307011/
_version_	1613180928574619648

Angioimmunoblastic T-Cell Lymphoma: A Diagnostic Challenge

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