Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series

Objective. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. (HSW), we provide a systematic review of case reports and case series about liver damage associated with...

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Main Authors:	Lei, Xiang, Chen, Jing, Ren, Jingtian, Li, Yan, Zhai, Jingbo, Mu, Wei, Zhang, Li, Zheng, Wenke, Tian, Guihua, Shang, Hongcai
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306360/

id	pubmed-4306360
recordtype	oai_dc
spelling	pubmed-43063602015-02-03 Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series Lei, Xiang Chen, Jing Ren, Jingtian Li, Yan Zhai, Jingbo Mu, Wei Zhang, Li Zheng, Wenke Tian, Guihua Shang, Hongcai Review Article Objective. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Methods. An extensive search of 6 medical databases was performed up to June 2014. Case reports and case series involving liver damage associated with HSW were included. Results. This review covers a total of 450 cases in 76 articles. HSW types included raw and processed HSW decoction pieces and many Chinese patent medicines that contain HSW. Symptoms of liver damage occur mostly a month or so after taking the medicine, mainly including jaundice, fatigue, anorexia, and yellow or tawny urine. Of the 450 patients, two cases who received liver transplantation and seven who died, the remaining 441 cases recovered or had liver function improvement after discontinuing HSW products and conservative care. Conclusion. HSW causes liver toxicity and may cause liver damage in different degrees and even lead to death; most of them are much related to long-term and overdose of drugs. Liver damage associated with HSW is reversible, and, after active treatment, the majority can be cured. People should be alert to liver damage when taking HSW preparations. Hindawi Publishing Corporation 2015 2015-01-12 /pmc/articles/PMC4306360/ /pubmed/25648693 http://dx.doi.org/10.1155/2015/459749 Text en Copyright © 2015 Xiang Lei et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Lei, Xiang Chen, Jing Ren, Jingtian Li, Yan Zhai, Jingbo Mu, Wei Zhang, Li Zheng, Wenke Tian, Guihua Shang, Hongcai
spellingShingle	Lei, Xiang Chen, Jing Ren, Jingtian Li, Yan Zhai, Jingbo Mu, Wei Zhang, Li Zheng, Wenke Tian, Guihua Shang, Hongcai Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series
author_facet	Lei, Xiang Chen, Jing Ren, Jingtian Li, Yan Zhai, Jingbo Mu, Wei Zhang, Li Zheng, Wenke Tian, Guihua Shang, Hongcai
author_sort	Lei, Xiang
title	Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series
title_short	Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series
title_full	Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series
title_fullStr	Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series
title_full_unstemmed	Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series
title_sort	liver damage associated with polygonum multiflorum thunb.: a systematic review of case reports and case series
description	Objective. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Methods. An extensive search of 6 medical databases was performed up to June 2014. Case reports and case series involving liver damage associated with HSW were included. Results. This review covers a total of 450 cases in 76 articles. HSW types included raw and processed HSW decoction pieces and many Chinese patent medicines that contain HSW. Symptoms of liver damage occur mostly a month or so after taking the medicine, mainly including jaundice, fatigue, anorexia, and yellow or tawny urine. Of the 450 patients, two cases who received liver transplantation and seven who died, the remaining 441 cases recovered or had liver function improvement after discontinuing HSW products and conservative care. Conclusion. HSW causes liver toxicity and may cause liver damage in different degrees and even lead to death; most of them are much related to long-term and overdose of drugs. Liver damage associated with HSW is reversible, and, after active treatment, the majority can be cured. People should be alert to liver damage when taking HSW preparations.
publisher	Hindawi Publishing Corporation
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306360/
_version_	1613180714966056960

Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series

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