Enhanced Amphiphilic Profile of a Short β-Stranded Peptide Improves Its Antimicrobial Activity

Enhanced Amphiphilic Profile of a Short β-Stranded Peptide Improves Its Antimicrobial Activity

SB056 is a novel semi-synthetic antimicrobial peptide with a dimeric dendrimer scaffold. Active against both Gram-negative and -positive bacteria, its mechanism has been attributed to a disruption of bacterial membranes. The branched peptide was shown to assume a β-stranded conformation in a lipidic...

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Bibliographic Details
Main Authors: Manzo, Giorgia, Scorciapino, Mariano A., Wadhwani, Parvesh, Bürck, Jochen, Montaldo, Nicola Pietro, Pintus, Manuela, Sanna, Roberta, Casu, Mariano, Giuliani, Andrea, Pirri, Giovanna, Luca, Vincenzo, Ulrich, Anne S., Rinaldi, Andrea C.
Format: Online
Language:English
Published: Public Library of Science 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305290/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305290/

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