Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

Germline variation at immunoglobulin (IG) loci is critical for pathogen-mediated immunity, but establishing complete haplotype sequences in these regions has been problematic because of complex sequence architecture and diploid source DNA. We sequenced BAC clones from the effectively haploid human h...

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Bibliographic Details
Main Authors: Watson, Corey T., Steinberg, Karyn Meltz, Graves, Tina A., Warren, Rene L., Malig, Maika, Schein, Jacqueline, Wilson, Richard K., Holt, Robert A., Eichler, Evan E., Breden, Felix
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304971/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304971/

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