Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis

Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant lit...

Full description

Bibliographic Details
Main Authors:	Yang, Boyi, Fan, Shujun, Zhi, Xueyuan, Wang, Yinuo, Wang, Yanxun, Zheng, Quanmei, Sun, Guifan
Format:	Online
Language:	English
Published:	MDPI 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303827/

id	pubmed-4303827
recordtype	oai_dc
spelling	pubmed-43038272015-02-02 Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis Yang, Boyi Fan, Shujun Zhi, Xueyuan Wang, Yinuo Wang, Yanxun Zheng, Quanmei Sun, Guifan Article Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant literature, and further manually screened reference lists and corresponded with original authors. Pooled prevalence of HHcy was calculated using random effects model. Subgroup analysis, meta-regression and sensitivity analysis were also performed. A total of 36 studies consisting 60,754 subjects (57.3% male; age range, 3–97 years) were finally included. The overall pooled prevalence of HHcy was 27.5%. Geographically, the prevalence was high in north areas, intermediate in central areas, and low in south areas, and was higher in inland versus coastal areas. The prevalence increased with age and was significantly higher in men than in women. Rural residents had a slightly higher HHcy prevalence than urban residents, and the studies conducted during 2006 to 2012 presented a higher HHcy prevalence than those during 1990 to 2005. In summary, the prevalence of HHcy in China is high, particularly in northern populations, the inlanders, males, and the elderly. Homocysteine-lowering strategies are necessary to reduce this highly preventable disorder. MDPI 2014-12-29 /pmc/articles/PMC4303827/ /pubmed/25551247 http://dx.doi.org/10.3390/nu7010074 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yang, Boyi Fan, Shujun Zhi, Xueyuan Wang, Yinuo Wang, Yanxun Zheng, Quanmei Sun, Guifan
spellingShingle	Yang, Boyi Fan, Shujun Zhi, Xueyuan Wang, Yinuo Wang, Yanxun Zheng, Quanmei Sun, Guifan Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis
author_facet	Yang, Boyi Fan, Shujun Zhi, Xueyuan Wang, Yinuo Wang, Yanxun Zheng, Quanmei Sun, Guifan
author_sort	Yang, Boyi
title	Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis
title_short	Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis
title_full	Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis
title_fullStr	Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis
title_full_unstemmed	Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis
title_sort	prevalence of hyperhomocysteinemia in china: a systematic review and meta-analysis
description	Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant literature, and further manually screened reference lists and corresponded with original authors. Pooled prevalence of HHcy was calculated using random effects model. Subgroup analysis, meta-regression and sensitivity analysis were also performed. A total of 36 studies consisting 60,754 subjects (57.3% male; age range, 3–97 years) were finally included. The overall pooled prevalence of HHcy was 27.5%. Geographically, the prevalence was high in north areas, intermediate in central areas, and low in south areas, and was higher in inland versus coastal areas. The prevalence increased with age and was significantly higher in men than in women. Rural residents had a slightly higher HHcy prevalence than urban residents, and the studies conducted during 2006 to 2012 presented a higher HHcy prevalence than those during 1990 to 2005. In summary, the prevalence of HHcy in China is high, particularly in northern populations, the inlanders, males, and the elderly. Homocysteine-lowering strategies are necessary to reduce this highly preventable disorder.
publisher	MDPI
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303827/
_version_	1613179855400075264

Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis

Similar Items