Neurotoxicity of intrathecal injections of dexmedetomidine into the rat spinal dorsal horn★

To investigate the neurotoxicity of intrathecal injections of dexmedetomidine, Sprague-Dawley rats were intrathecally injected with dexmedetomidine at doses of 0.75, 1.50 and 3.00 μg/kg into the spinal dorsal horn. We found that c-Fos expression in the rat spinal dorsal horn peaked at 7 hours follow...

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Bibliographic Details
Main Authors: Hou, Jiabao, Xia, Zhongyuan, Xiao, Xingpeng, Wan, Xing, Zhao, Bo
Format: Online
Language:English
Published: Medknow Publications & Media Pvt Ltd 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302524/