Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature

Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature

The present study reports a rare case of primitive neuroectodermal tumor (PNET) of the prostate. A 23-year-old male presented to Oita Medical Center (Oita, Japan) with the complaint of dysuria and anal pain. A large mass in the prostate and a number of swollen lymph nodes in the pelvic region were i...

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Main Authors: SHIBUYA, TADAMASA, MORI, KENICHI, SUMINO, YASUHIRO, SATO, FUMINORI, MIMATA, HIROMITSU
Format: Online
Language:English
Published: D.A. Spandidos 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301542/
id pubmed-4301542
recordtype oai_dc
spelling pubmed-43015422015-01-26 Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature SHIBUYA, TADAMASA MORI, KENICHI SUMINO, YASUHIRO SATO, FUMINORI MIMATA, HIROMITSU Articles The present study reports a rare case of primitive neuroectodermal tumor (PNET) of the prostate. A 23-year-old male presented to Oita Medical Center (Oita, Japan) with the complaint of dysuria and anal pain. A large mass in the prostate and a number of swollen lymph nodes in the pelvic region were identified by a computed tomography scan and magnetic resonance imaging. The patient was, thus, admitted to Oita University Hospital (Yufu, Japan), where a biopsy of the prostate gland was performed. Histological analysis revealed small round cells that were positive for MIC-2 expression and fluorescent in situ hybridization analysis detected a translocation involving Ewing sarcoma breakpoint region 1 at chromosome 22q12. Thus, a diagnosis of PNET of the prostate was established. Systemic chemotherapy was the selected treatment, however, a poor response was obtained. The patient succumbed approximately four months after the initial onset of symptoms. PNET of the prostate has been reported in eight cases worldwide; in comparison, the present case exhibited the most unsatisfactory outcome. D.A. Spandidos 2015-02 2014-11-24 /pmc/articles/PMC4301542/ /pubmed/25624891 http://dx.doi.org/10.3892/ol.2014.2731 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author SHIBUYA, TADAMASA
MORI, KENICHI
SUMINO, YASUHIRO
SATO, FUMINORI
MIMATA, HIROMITSU
spellingShingle SHIBUYA, TADAMASA
MORI, KENICHI
SUMINO, YASUHIRO
SATO, FUMINORI
MIMATA, HIROMITSU
Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
author_facet SHIBUYA, TADAMASA
MORI, KENICHI
SUMINO, YASUHIRO
SATO, FUMINORI
MIMATA, HIROMITSU
author_sort SHIBUYA, TADAMASA
title Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title_short Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title_full Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title_fullStr Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title_full_unstemmed Rapidly progressive primitive neuroectodermal tumor of the prostate: A case report and review of the literature
title_sort rapidly progressive primitive neuroectodermal tumor of the prostate: a case report and review of the literature
description The present study reports a rare case of primitive neuroectodermal tumor (PNET) of the prostate. A 23-year-old male presented to Oita Medical Center (Oita, Japan) with the complaint of dysuria and anal pain. A large mass in the prostate and a number of swollen lymph nodes in the pelvic region were identified by a computed tomography scan and magnetic resonance imaging. The patient was, thus, admitted to Oita University Hospital (Yufu, Japan), where a biopsy of the prostate gland was performed. Histological analysis revealed small round cells that were positive for MIC-2 expression and fluorescent in situ hybridization analysis detected a translocation involving Ewing sarcoma breakpoint region 1 at chromosome 22q12. Thus, a diagnosis of PNET of the prostate was established. Systemic chemotherapy was the selected treatment, however, a poor response was obtained. The patient succumbed approximately four months after the initial onset of symptoms. PNET of the prostate has been reported in eight cases worldwide; in comparison, the present case exhibited the most unsatisfactory outcome.
publisher D.A. Spandidos
publishDate 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301542/
_version_ 1613178994701631488

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