Creating an African HIV Clinical Research and Prevention Trials Network: HIV Prevalence, Incidence and Transmission

HIV epidemiology informs prevention trial design and program planning. Nine clinical research centers (CRC) in sub-Saharan Africa conducted HIV observational epidemiology studies in populations at risk for HIV infection as part of an HIV prevention and vaccine trial network. Annual HIV incidence ran...

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Main Authors:	Kamali, Anatoli, Price, Matt A., Lakhi, Shabir, Karita, Etienne, Inambao, Mubiana, Sanders, Eduard J., Anzala, Omu, Latka, Mary H., Bekker, Linda-Gail, Kaleebu, Pontiano, Asiki, Gershim, Ssetaala, Ali, Ruzagira, Eugene, Allen, Susan, Farmer, Paul, Hunter, Eric, Mutua, Gaudensia, Makkan, Heeran, Tichacek, Amanda, Brill, Ilene K., Fast, Pat, Stevens, Gwynn, Chetty, Paramesh, Amornkul, Pauli N., Gilmour, Jill
Format:	Online
Language:	English
Published:	Public Library of Science 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300215/

id	pubmed-4300215
recordtype	oai_dc
spelling	pubmed-43002152015-01-30 Creating an African HIV Clinical Research and Prevention Trials Network: HIV Prevalence, Incidence and Transmission Kamali, Anatoli Price, Matt A. Lakhi, Shabir Karita, Etienne Inambao, Mubiana Sanders, Eduard J. Anzala, Omu Latka, Mary H. Bekker, Linda-Gail Kaleebu, Pontiano Asiki, Gershim Ssetaala, Ali Ruzagira, Eugene Allen, Susan Farmer, Paul Hunter, Eric Mutua, Gaudensia Makkan, Heeran Tichacek, Amanda Brill, Ilene K. Fast, Pat Stevens, Gwynn Chetty, Paramesh Amornkul, Pauli N. Gilmour, Jill Research Article HIV epidemiology informs prevention trial design and program planning. Nine clinical research centers (CRC) in sub-Saharan Africa conducted HIV observational epidemiology studies in populations at risk for HIV infection as part of an HIV prevention and vaccine trial network. Annual HIV incidence ranged from below 2% to above 10% and varied by CRC and risk group, with rates above 5% observed in Zambian men in an HIV-discordant relationship, Ugandan men from Lake Victoria fishing communities, men who have sex with men, and several cohorts of women. HIV incidence tended to fall after the first three months in the study and over calendar time. Among suspected transmission pairs, 28% of HIV infections were not from the reported partner. Volunteers with high incidence were successfully identified and enrolled into large scale cohort studies. Over a quarter of new cases in couples acquired infection from persons other than the suspected transmitting partner. Public Library of Science 2015-01-20 /pmc/articles/PMC4300215/ /pubmed/25602351 http://dx.doi.org/10.1371/journal.pone.0116100 Text en © 2015 Kamali et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kamali, Anatoli Price, Matt A. Lakhi, Shabir Karita, Etienne Inambao, Mubiana Sanders, Eduard J. Anzala, Omu Latka, Mary H. Bekker, Linda-Gail Kaleebu, Pontiano Asiki, Gershim Ssetaala, Ali Ruzagira, Eugene Allen, Susan Farmer, Paul Hunter, Eric Mutua, Gaudensia Makkan, Heeran Tichacek, Amanda Brill, Ilene K. Fast, Pat Stevens, Gwynn Chetty, Paramesh Amornkul, Pauli N. Gilmour, Jill
spellingShingle	Kamali, Anatoli Price, Matt A. Lakhi, Shabir Karita, Etienne Inambao, Mubiana Sanders, Eduard J. Anzala, Omu Latka, Mary H. Bekker, Linda-Gail Kaleebu, Pontiano Asiki, Gershim Ssetaala, Ali Ruzagira, Eugene Allen, Susan Farmer, Paul Hunter, Eric Mutua, Gaudensia Makkan, Heeran Tichacek, Amanda Brill, Ilene K. Fast, Pat Stevens, Gwynn Chetty, Paramesh Amornkul, Pauli N. Gilmour, Jill Creating an African HIV Clinical Research and Prevention Trials Network: HIV Prevalence, Incidence and Transmission
author_facet	Kamali, Anatoli Price, Matt A. Lakhi, Shabir Karita, Etienne Inambao, Mubiana Sanders, Eduard J. Anzala, Omu Latka, Mary H. Bekker, Linda-Gail Kaleebu, Pontiano Asiki, Gershim Ssetaala, Ali Ruzagira, Eugene Allen, Susan Farmer, Paul Hunter, Eric Mutua, Gaudensia Makkan, Heeran Tichacek, Amanda Brill, Ilene K. Fast, Pat Stevens, Gwynn Chetty, Paramesh Amornkul, Pauli N. Gilmour, Jill
author_sort	Kamali, Anatoli
title	Creating an African HIV Clinical Research and Prevention Trials Network: HIV Prevalence, Incidence and Transmission
title_short	Creating an African HIV Clinical Research and Prevention Trials Network: HIV Prevalence, Incidence and Transmission
title_full	Creating an African HIV Clinical Research and Prevention Trials Network: HIV Prevalence, Incidence and Transmission
title_fullStr	Creating an African HIV Clinical Research and Prevention Trials Network: HIV Prevalence, Incidence and Transmission
title_full_unstemmed	Creating an African HIV Clinical Research and Prevention Trials Network: HIV Prevalence, Incidence and Transmission
title_sort	creating an african hiv clinical research and prevention trials network: hiv prevalence, incidence and transmission
description	HIV epidemiology informs prevention trial design and program planning. Nine clinical research centers (CRC) in sub-Saharan Africa conducted HIV observational epidemiology studies in populations at risk for HIV infection as part of an HIV prevention and vaccine trial network. Annual HIV incidence ranged from below 2% to above 10% and varied by CRC and risk group, with rates above 5% observed in Zambian men in an HIV-discordant relationship, Ugandan men from Lake Victoria fishing communities, men who have sex with men, and several cohorts of women. HIV incidence tended to fall after the first three months in the study and over calendar time. Among suspected transmission pairs, 28% of HIV infections were not from the reported partner. Volunteers with high incidence were successfully identified and enrolled into large scale cohort studies. Over a quarter of new cases in couples acquired infection from persons other than the suspected transmitting partner.
publisher	Public Library of Science
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300215/
_version_	1613178586097778688

Creating an African HIV Clinical Research and Prevention Trials Network: HIV Prevalence, Incidence and Transmission

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