The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans
The vestibulo-ocular reflex (VOR) shows frequency-dependent behavior. This study investigated whether the characteristics of the electrically evoked VOR (eVOR) elicited by a vestibular implant, showed the same frequency-dependency. Twelve vestibular electrodes implanted in seven patients with bilate...
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| Format: | Online |
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Frontiers Media S.A.
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299437/ |
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pubmed-42994372015-02-04 The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans van de Berg, Raymond Guinand, Nils Nguyen, T. A. Khoa Ranieri, Maurizio Cavuscens, Samuel Guyot, Jean-Philippe Stokroos, Robert Kingma, Herman Perez-Fornos, Angelica Neuroscience The vestibulo-ocular reflex (VOR) shows frequency-dependent behavior. This study investigated whether the characteristics of the electrically evoked VOR (eVOR) elicited by a vestibular implant, showed the same frequency-dependency. Twelve vestibular electrodes implanted in seven patients with bilateral vestibular hypofunction (BVH) were tested. Stimuli consisted of amplitude-modulated electrical stimulation with a sinusoidal profile at frequencies of 0.5, 1, and 2 Hz. The main characteristics of the eVOR were evaluated and compared to the “natural” VOR characteristics measured in a group of age-matched healthy volunteers who were subjected to horizontal whole body rotations with equivalent sinusoidal velocity profiles at the same frequencies. A strong and significant effect of frequency was observed in the total peak eye velocity of the eVOR. This effect was similar to that observed in the “natural” VOR. Other characteristics of the (e)VOR (angle, habituation-index, and asymmetry) showed no significant frequency-dependent effect. In conclusion, this study demonstrates that, at least at the specific (limited) frequency range tested, responses elicited by a vestibular implant closely mimic the frequency-dependency of the “normal” vestibular system. Frontiers Media S.A. 2015-01-20 /pmc/articles/PMC4299437/ /pubmed/25653601 http://dx.doi.org/10.3389/fnsys.2014.00255 Text en Copyright © 2015 van de Berg, Guinand, Nguyen, Ranieri, Cavuscens, Guyot, Stokroos, Kingma and Perez-Fornos. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
van de Berg, Raymond Guinand, Nils Nguyen, T. A. Khoa Ranieri, Maurizio Cavuscens, Samuel Guyot, Jean-Philippe Stokroos, Robert Kingma, Herman Perez-Fornos, Angelica |
| spellingShingle |
van de Berg, Raymond Guinand, Nils Nguyen, T. A. Khoa Ranieri, Maurizio Cavuscens, Samuel Guyot, Jean-Philippe Stokroos, Robert Kingma, Herman Perez-Fornos, Angelica The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans |
| author_facet |
van de Berg, Raymond Guinand, Nils Nguyen, T. A. Khoa Ranieri, Maurizio Cavuscens, Samuel Guyot, Jean-Philippe Stokroos, Robert Kingma, Herman Perez-Fornos, Angelica |
| author_sort |
van de Berg, Raymond |
| title |
The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans |
| title_short |
The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans |
| title_full |
The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans |
| title_fullStr |
The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans |
| title_full_unstemmed |
The vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans |
| title_sort |
vestibular implant: frequency-dependency of the electrically evoked vestibulo-ocular reflex in humans |
| description |
The vestibulo-ocular reflex (VOR) shows frequency-dependent behavior. This study investigated whether the characteristics of the electrically evoked VOR (eVOR) elicited by a vestibular implant, showed the same frequency-dependency. Twelve vestibular electrodes implanted in seven patients with bilateral vestibular hypofunction (BVH) were tested. Stimuli consisted of amplitude-modulated electrical stimulation with a sinusoidal profile at frequencies of 0.5, 1, and 2 Hz. The main characteristics of the eVOR were evaluated and compared to the “natural” VOR characteristics measured in a group of age-matched healthy volunteers who were subjected to horizontal whole body rotations with equivalent sinusoidal velocity profiles at the same frequencies. A strong and significant effect of frequency was observed in the total peak eye velocity of the eVOR. This effect was similar to that observed in the “natural” VOR. Other characteristics of the (e)VOR (angle, habituation-index, and asymmetry) showed no significant frequency-dependent effect. In conclusion, this study demonstrates that, at least at the specific (limited) frequency range tested, responses elicited by a vestibular implant closely mimic the frequency-dependency of the “normal” vestibular system. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299437/ |
| _version_ |
1613178334019059712 |