Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1

Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1

Individuals with neurofibromatosis type 1 (NF1) frequently exhibit cognitive and motor impairments and characteristics of autism. The cerebellum plays a critical role in motor control, cognition, and social interaction, suggesting that cerebellar defects likely contribute to NF1-associated neurodeve...

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Bibliographic Details
Main Authors: Kim, Edward, Wang, Yuan, Kim, Sun-Jung, Bornhorst, Miriam, Jecrois, Emmanuelle S, Anthony, Todd E, Wang, Chenran, Li, Yi E, Guan, Jun-Lin, Murphy, Geoffrey G, Zhu, Yuan
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297949/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297949/

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