Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells

Endogenous WNT Signals Mediate BMP-Induced and Spontaneous Differentiation of Epiblast Stem Cells and Human Embryonic Stem Cells

Therapeutic application of human embryonic stem cells (hESCs) requires precise control over their differentiation. However, spontaneous differentiation is prevalent, and growth factors induce multiple cell types; e.g., the mesoderm inducer BMP4 generates both mesoderm and trophoblast. Here we identi...

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Bibliographic Details
Main Authors: Kurek, Dorota, Neagu, Alex, Tastemel, Melodi, Tüysüz, Nesrin, Lehmann, Johannes, van de Werken, Harmen J.G., Philipsen, Sjaak, van der Linden, Reinier, Maas, Alex, van IJcken, Wilfred F.J., Drukker, Micha, ten Berge, Derk
Format: Online
Language:English
Published: Elsevier 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297870/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297870/

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