| Summary: | Acute renal damage mainly develops following toxic or ischemic insults and is defined as
acute. These damages have largely been attributed to oxidative stress. Recently much
attention has been directed toward decreased renal tubular cell regeneration during tubular cell injury. Antioxidants have recently been the focus of researchers and scientists
for prevention and treatment of various oxidative stress-related conditions, including renal
toxicities. Although free radicals are known to contribute in kidney injury and abundant
researches, particularly laboratory trials, have shown the beneficial effects of antioxidants
against these complications, long term clinical trials do not uniformly confirm this matter,
especially for single antioxidant consumption such as vitamin C. The aim of this paper is
to discuss the possible explanation of this matter.
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