Ewing Sarcoma of the Posterior Fossa in an Adolescent Girl
Medulloblastoma, astrocytoma, and ependymoma represent the most common infratentorial tumors in childhood, while Ewing sarcomas in that localization are extremely rare. A large left infratentorial space-occupying lesion was diagnosed in a 12-year-old girl with signs of increased intracranial pressur...
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| Format: | Online |
| Language: | English |
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Hindawi Publishing Corporation
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295441/ |
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pubmed-4295441 |
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pubmed-42954412015-01-22 Ewing Sarcoma of the Posterior Fossa in an Adolescent Girl Stark, Andreas M. Leuschner, Ivo Mehdorn, H. Maximilian Claviez, Alexander Case Report Medulloblastoma, astrocytoma, and ependymoma represent the most common infratentorial tumors in childhood, while Ewing sarcomas in that localization are extremely rare. A large left infratentorial space-occupying lesion was diagnosed in a 12-year-old girl with signs of increased intracranial pressure. Following total tumor resection, histological and molecular examination revealed Ewing sarcoma with rearranged EWSR-1 gene. The patient achieved complete remission following adjuvant chemotherapy and radiotherapy according to Euro-EWING 2008 treatment protocol. Intracranial Ewing sarcoma, although rare, should be an important differential diagnosis of intracranial tumors in childhood which requires aggressive multimodal treatment. Hindawi Publishing Corporation 2014 2014-12-29 /pmc/articles/PMC4295441/ /pubmed/25614743 http://dx.doi.org/10.1155/2014/439830 Text en Copyright © 2014 Andreas M. Stark et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Stark, Andreas M. Leuschner, Ivo Mehdorn, H. Maximilian Claviez, Alexander |
| spellingShingle |
Stark, Andreas M. Leuschner, Ivo Mehdorn, H. Maximilian Claviez, Alexander Ewing Sarcoma of the Posterior Fossa in an Adolescent Girl |
| author_facet |
Stark, Andreas M. Leuschner, Ivo Mehdorn, H. Maximilian Claviez, Alexander |
| author_sort |
Stark, Andreas M. |
| title |
Ewing Sarcoma of the Posterior Fossa in an Adolescent Girl |
| title_short |
Ewing Sarcoma of the Posterior Fossa in an Adolescent Girl |
| title_full |
Ewing Sarcoma of the Posterior Fossa in an Adolescent Girl |
| title_fullStr |
Ewing Sarcoma of the Posterior Fossa in an Adolescent Girl |
| title_full_unstemmed |
Ewing Sarcoma of the Posterior Fossa in an Adolescent Girl |
| title_sort |
ewing sarcoma of the posterior fossa in an adolescent girl |
| description |
Medulloblastoma, astrocytoma, and ependymoma represent the most common infratentorial tumors in childhood, while Ewing sarcomas in that localization are extremely rare. A large left infratentorial space-occupying lesion was diagnosed in a 12-year-old girl with signs of increased intracranial pressure. Following total tumor resection, histological and molecular examination revealed Ewing sarcoma with rearranged EWSR-1 gene. The patient achieved complete remission following adjuvant chemotherapy and radiotherapy according to Euro-EWING 2008 treatment protocol. Intracranial Ewing sarcoma, although rare, should be an important differential diagnosis of intracranial tumors in childhood which requires aggressive multimodal treatment. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295441/ |
| _version_ |
1613176986686980096 |