Rapid modeling of cooperating genetic events in cancer through somatic genome editing

Cancer is a multistep process that involves mutations and other alterations in oncogenes and tumor suppressor genes1. Genome sequencing studies have identified a large collection of genetic alterations that occur in human cancers2–4. However, the determination of which mutations are causally related...

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Bibliographic Details
Main Authors: Sánchez-Rivera, Francisco J., Papagiannakopoulos, Thales, Romero, Rodrigo, Tammela, Tuomas, Bauer, Matthew R., Bhutkar, Arjun, Joshi, Nikhil S., Subbaraj, Lakshmipriya, Bronson, Roderick T., Xue, Wen, Jacks, Tyler
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292871/