The Role of Endothelin-1 and Endothelin Receptor Antagonists in Inflammatory Response and Sepsis
Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species. It is claimed...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Springer Basel
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289534/ |