Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes

Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes

Clinical outcome of children with malignant glioma remains dismal. Here, we examined the role of over-expressed BMI1, a regulator of stem cell self-renewal, in sustaining tumor formation in pediatric glioma stem cells. Our investigation revealed BMI1 over-expression in 29 of 54 (53.7%) pediatric gli...

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Bibliographic Details
Main Authors: Baxter, Patricia A, Lin, Qi, Mao, Hua, Kogiso, Mari, Zhao, Xiumei, Liu, Zhigang, Huang, Yulun, Voicu, Horatiu, Gurusiddappa, Sivashankarappa, Su, Jack M, Adesina, Adekunle M, Perlaky, Laszlo, Dauser, Robert C, Leung, Hon-chiu Eastwood, Muraszko, Karin M, Heth, Jason A, Fan, Xing, Lau, Ching C, Man, Tsz-Kwong, Chintagumpala, Murali, Li, Xiao-Nan
Format: Online
Language:English
Published: BioMed Central 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289398/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289398/

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