Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5, oxidatively demethylate abundant N6-methyladenosine (m6A) residues in mRNA. Achieving a method for selective inhibition of FTO over ALKBH5 remains a challenge, however. Here, we have identified meclofenamic acid (MA...

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Bibliographic Details
Main Authors: Huang, Yue, Yan, Jingli, Li, Qi, Li, Jiafei, Gong, Shouzhe, Zhou, Hu, Gan, Jianhua, Jiang, Hualiang, Jia, Gui-Fang, Luo, Cheng, Yang, Cai-Guang
Format: Online
Language:English
Published: Oxford University Press 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288171/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288171/

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