Suppressing nonsense—a surprising function for 5-azacytidine
In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but that in certain cases can be detrimental becau...
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| Format: | Online |
| Language: | English |
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BlackWell Publishing Ltd
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287971/ |
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pubmed-4287971 |
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pubmed-42879712015-01-12 Suppressing nonsense—a surprising function for 5-azacytidine Shao, Ada Wilkinson, Miles F Closeups In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but that in certain cases can be detrimental because it eliminates “useful” garbage. The chemical inhibitor identified by Bhuvanagiri et al perturbs Nonsense-Mediated RNA Decay (NMD), a RNA surveillance pathway that targets mRNAs harboring premature termination codons (PTCs) for degradation (Kervestin & Jacobson, 2012). BlackWell Publishing Ltd 2014-12 2014-11-06 /pmc/articles/PMC4287971/ /pubmed/25378479 http://dx.doi.org/10.15252/emmm.201404569 Text en © 2014 The Authors. Published under the terms of the CC BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Shao, Ada Wilkinson, Miles F |
| spellingShingle |
Shao, Ada Wilkinson, Miles F Suppressing nonsense—a surprising function for 5-azacytidine |
| author_facet |
Shao, Ada Wilkinson, Miles F |
| author_sort |
Shao, Ada |
| title |
Suppressing nonsense—a surprising function for 5-azacytidine |
| title_short |
Suppressing nonsense—a surprising function for 5-azacytidine |
| title_full |
Suppressing nonsense—a surprising function for 5-azacytidine |
| title_fullStr |
Suppressing nonsense—a surprising function for 5-azacytidine |
| title_full_unstemmed |
Suppressing nonsense—a surprising function for 5-azacytidine |
| title_sort |
suppressing nonsense—a surprising function for 5-azacytidine |
| description |
In this issue of EMBO Molecular Medicine, Bhuvanagiri
et al report on a chemical means to convert molecular junk into gold. They
identify a chemical inhibitor of a quality control pathway that is best known for its ability to
clear cells of rubbish, but that in certain cases can be detrimental because it eliminates
“useful” garbage. The chemical inhibitor identified by Bhuvanagiri
et al perturbs Nonsense-Mediated RNA Decay (NMD), a RNA surveillance pathway
that targets mRNAs harboring premature termination codons (PTCs) for degradation (Kervestin &
Jacobson, 2012). |
| publisher |
BlackWell Publishing Ltd |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287971/ |
| _version_ |
1613174557082910720 |