The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

Estetrol (E4) is a natural estrogen with a long half-life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand-binding domain bound to 17β-estradiol (E2) and E4 are very similar, as well as their capacity to activate the two activati...

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Bibliographic Details
Main Authors: Abot, Anne, Fontaine, Coralie, Buscato, Mélissa, Solinhac, Romain, Flouriot, Gilles, Fabre, Aurélie, Drougard, Anne, Rajan, Shyamala, Laine, Muriel, Milon, Alain, Muller, Isabelle, Henrion, Daniel, Adlanmerini, Marine, Valéra, Marie-Cécile, Gompel, Anne, Gerard, Céline, Péqueux, Christel, Mestdagt, Mélanie, Raymond-Letron, Isabelle, Knauf, Claude, Ferriere, François, Valet, Philippe, Gourdy, Pierre, Katzenellenbogen, Benita S, Katzenellenbogen, John A, Lenfant, Françoise, Greene, Geoffrey L, Foidart, Jean-Michel, Arnal, Jean-François
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287935/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287935/

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