Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37

Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37

The effect of the anti-inflammatory cytokine interleukin-37 (IL-37) on host defense against Candida infections remains unknown. We assessed the role of IL-37 in a murine model of disseminated candidiasis using mice transgenic for human IL-37 (hIL-37Tg). Upon exposure to Candida albicans pseudohyphae...

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Bibliographic Details
Main Authors: van de Veerdonk, Frank L., Gresnigt, Mark S., Oosting, Marije, van der Meer, Jos W. M., Joosten, Leo A. B., Netea, Mihai G., Dinarello, Charles A.
Format: Online
Language:English
Published: Frontiers Media S.A. 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285810/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285810/

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