Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness

Progress in neuroimaging has yielded new powerful tools which, potentially, can be applied to clinical populations, improve the diagnosis of neurological disorders and predict outcome. At present, the diagnosis of consciousness disorders is limited to subjective assessment and objective measurements...

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Main Authors:	Cavaliere, Carlo, Aiello, Marco, Di Perri, Carol, Fernandez-Espejo, Davinia, Owen, Adrian M., Soddu, Andrea
Format:	Online
Language:	English
Published:	Frontiers Media S.A. 2015
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285098/

id	pubmed-4285098
recordtype	oai_dc
spelling	pubmed-42850982015-01-21 Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness Cavaliere, Carlo Aiello, Marco Di Perri, Carol Fernandez-Espejo, Davinia Owen, Adrian M. Soddu, Andrea Neuroscience Progress in neuroimaging has yielded new powerful tools which, potentially, can be applied to clinical populations, improve the diagnosis of neurological disorders and predict outcome. At present, the diagnosis of consciousness disorders is limited to subjective assessment and objective measurements of behavior, with an emerging role for neuroimaging techniques. In this review we focus on white matter alterations measured using Diffusion Tensor Imaging on patients with consciousness disorders, examining the most common diffusion imaging acquisition protocols and considering the main issues related to diffusion imaging analyses. We conclude by considering some of the remaining challenges to overcome, the existing knowledge gaps and the potential role of neuroimaging in understanding the pathogenesis and clinical features of disorders of consciousness. Frontiers Media S.A. 2015-01-06 /pmc/articles/PMC4285098/ /pubmed/25610388 http://dx.doi.org/10.3389/fnhum.2014.01028 Text en Copyright © 2015 Cavaliere, Aiello, Di Perri, Fernandez-Espejo, Owen and Soddu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Cavaliere, Carlo Aiello, Marco Di Perri, Carol Fernandez-Espejo, Davinia Owen, Adrian M. Soddu, Andrea
spellingShingle	Cavaliere, Carlo Aiello, Marco Di Perri, Carol Fernandez-Espejo, Davinia Owen, Adrian M. Soddu, Andrea Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness
author_facet	Cavaliere, Carlo Aiello, Marco Di Perri, Carol Fernandez-Espejo, Davinia Owen, Adrian M. Soddu, Andrea
author_sort	Cavaliere, Carlo
title	Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness
title_short	Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness
title_full	Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness
title_fullStr	Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness
title_full_unstemmed	Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness
title_sort	diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness
description	Progress in neuroimaging has yielded new powerful tools which, potentially, can be applied to clinical populations, improve the diagnosis of neurological disorders and predict outcome. At present, the diagnosis of consciousness disorders is limited to subjective assessment and objective measurements of behavior, with an emerging role for neuroimaging techniques. In this review we focus on white matter alterations measured using Diffusion Tensor Imaging on patients with consciousness disorders, examining the most common diffusion imaging acquisition protocols and considering the main issues related to diffusion imaging analyses. We conclude by considering some of the remaining challenges to overcome, the existing knowledge gaps and the potential role of neuroimaging in understanding the pathogenesis and clinical features of disorders of consciousness.
publisher	Frontiers Media S.A.
publishDate	2015
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285098/
_version_	1613173671780679680

Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness

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