Pituitary adenylate cyclase activating polypeptide and migraine
Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with mo...
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| Format: | Online |
| Language: | English |
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Blackwell Publishing Ltd
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284128/ |
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pubmed-4284128 |
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pubmed-42841282015-01-08 Pituitary adenylate cyclase activating polypeptide and migraine Zagami, Alessandro S Edvinsson, Lars Goadsby, Peter J Brief Communications Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced interictally (n = 9). The data suggest PACAP, or its receptors, are a promising target for migraine therapeutics. Blackwell Publishing Ltd 2014-12 2014-11-12 /pmc/articles/PMC4284128/ /pubmed/25574477 http://dx.doi.org/10.1002/acn3.113 Text en © 2014 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Zagami, Alessandro S Edvinsson, Lars Goadsby, Peter J |
| spellingShingle |
Zagami, Alessandro S Edvinsson, Lars Goadsby, Peter J Pituitary adenylate cyclase activating polypeptide and migraine |
| author_facet |
Zagami, Alessandro S Edvinsson, Lars Goadsby, Peter J |
| author_sort |
Zagami, Alessandro S |
| title |
Pituitary adenylate cyclase activating polypeptide and migraine |
| title_short |
Pituitary adenylate cyclase activating polypeptide and migraine |
| title_full |
Pituitary adenylate cyclase activating polypeptide and migraine |
| title_fullStr |
Pituitary adenylate cyclase activating polypeptide and migraine |
| title_full_unstemmed |
Pituitary adenylate cyclase activating polypeptide and migraine |
| title_sort |
pituitary adenylate cyclase activating polypeptide and migraine |
| description |
Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced interictally (n = 9). The data suggest PACAP, or its receptors, are a promising target for migraine therapeutics. |
| publisher |
Blackwell Publishing Ltd |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284128/ |
| _version_ |
1613173318731431936 |