Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation

Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation

CTLA-4 is a costimulatory molecule that negatively regulates T cell activation. Originally identified in murine CD8+ T cells, it has been found to be rapidly induced on human T cells. Furthermore, CTLA-4 is expressed on regulatory T cells (Tregs). Clinically, targeting CTLA-4 has clinical utility in...

Full description

Bibliographic Details
Main Authors: Chan, Derek V., Gibson, Heather M., Aufiero, Barbara M., Wilson, Adam J., Hafner, Mikehl S., Mi, Qing-Sheng, Wong, Henry K.
Format: Online
Language:English
Published: 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284071/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284071/

Similar Items