Physical Activity in Schizophrenia is Higher in the First Episode than in Subsequent Ones
Schizophrenia is frequently associated with abnormal motor behavior, particularly hypokinesia. The course of the illness tends to deteriorate in the first years. We aimed to assess gross motor activity in patients with a first episode (n = 33) and multiple episodes (n = 115) of schizophrenia spectru...
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| Format: | Online |
| Language: | English |
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Frontiers Media S.A.
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283447/ |
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pubmed-4283447 |
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pubmed-42834472015-01-19 Physical Activity in Schizophrenia is Higher in the First Episode than in Subsequent Ones Walther, Sebastian Stegmayer, Katharina Horn, Helge Razavi, Nadja Müller, Thomas J. Strik, Werner Psychiatry Schizophrenia is frequently associated with abnormal motor behavior, particularly hypokinesia. The course of the illness tends to deteriorate in the first years. We aimed to assess gross motor activity in patients with a first episode (n = 33) and multiple episodes (n = 115) of schizophrenia spectrum disorders using wrist actigraphy. First episode patients were younger, had higher motor activity and reduced negative symptom severity. Covarying for age, chlorpromazine equivalents, and negative symptoms, first episode patients still had higher motor activity. This was also true after excluding patients with schizophreniform disorder from the analyses. In first episode patients, but not in patients with multiple episodes, motor activity was correlated with antipsychotic dosage. In conclusion, after controlling for variables related to disorder chronicity, patients with first episodes were still more active than patients with multiple episodes. Thus, reduced motor activity is a marker of deterioration in the course of schizophrenia spectrum disorders. Frontiers Media S.A. 2015-01-05 /pmc/articles/PMC4283447/ /pubmed/25601842 http://dx.doi.org/10.3389/fpsyt.2014.00191 Text en Copyright © 2015 Walther, Stegmayer, Horn, Razavi, Müller and Strik. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Walther, Sebastian Stegmayer, Katharina Horn, Helge Razavi, Nadja Müller, Thomas J. Strik, Werner |
| spellingShingle |
Walther, Sebastian Stegmayer, Katharina Horn, Helge Razavi, Nadja Müller, Thomas J. Strik, Werner Physical Activity in Schizophrenia is Higher in the First Episode than in Subsequent Ones |
| author_facet |
Walther, Sebastian Stegmayer, Katharina Horn, Helge Razavi, Nadja Müller, Thomas J. Strik, Werner |
| author_sort |
Walther, Sebastian |
| title |
Physical Activity in Schizophrenia is Higher in the First Episode than in Subsequent Ones |
| title_short |
Physical Activity in Schizophrenia is Higher in the First Episode than in Subsequent Ones |
| title_full |
Physical Activity in Schizophrenia is Higher in the First Episode than in Subsequent Ones |
| title_fullStr |
Physical Activity in Schizophrenia is Higher in the First Episode than in Subsequent Ones |
| title_full_unstemmed |
Physical Activity in Schizophrenia is Higher in the First Episode than in Subsequent Ones |
| title_sort |
physical activity in schizophrenia is higher in the first episode than in subsequent ones |
| description |
Schizophrenia is frequently associated with abnormal motor behavior, particularly hypokinesia. The course of the illness tends to deteriorate in the first years. We aimed to assess gross motor activity in patients with a first episode (n = 33) and multiple episodes (n = 115) of schizophrenia spectrum disorders using wrist actigraphy. First episode patients were younger, had higher motor activity and reduced negative symptom severity. Covarying for age, chlorpromazine equivalents, and negative symptoms, first episode patients still had higher motor activity. This was also true after excluding patients with schizophreniform disorder from the analyses. In first episode patients, but not in patients with multiple episodes, motor activity was correlated with antipsychotic dosage. In conclusion, after controlling for variables related to disorder chronicity, patients with first episodes were still more active than patients with multiple episodes. Thus, reduced motor activity is a marker of deterioration in the course of schizophrenia spectrum disorders. |
| publisher |
Frontiers Media S.A. |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283447/ |
| _version_ |
1613173055544098816 |