Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery
The study of stem-cell biology has been a flourishing research area because of its multi-differentiation potential. The emergence of induced pluripotent stem cells (iPSCs) open up the possibility of addressing obstructs, such as the limited cell source, inherent complexity of the human brain, and et...
| Main Authors: | , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Springer Milan
2014
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282683/ |
| id |
pubmed-4282683 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-42826832015-01-08 Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery Xie, Y. Z. Zhang, R. X. Review Article The study of stem-cell biology has been a flourishing research area because of its multi-differentiation potential. The emergence of induced pluripotent stem cells (iPSCs) open up the possibility of addressing obstructs, such as the limited cell source, inherent complexity of the human brain, and ethical constrains. Though still at its infancy phase, reprogramming of somatic cells has been demonstrating the ability to enhance in vitro study of neurodegenerative diseases and potential treatment. However, iPSCs would not thoroughly translate to the clinic before limitations are addressed. In this review, by summarizing the recent development of iPSC-based models, we will discuss the feasibility of iPSC technology on relevant diseases depth and illustrate how this new tool applies to drug screening and celluar therapy. Springer Milan 2014-10-30 2015 /pmc/articles/PMC4282683/ /pubmed/25354658 http://dx.doi.org/10.1007/s10072-014-1989-9 Text en © The Author(s) 2014 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Xie, Y. Z. Zhang, R. X. |
| spellingShingle |
Xie, Y. Z. Zhang, R. X. Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery |
| author_facet |
Xie, Y. Z. Zhang, R. X. |
| author_sort |
Xie, Y. Z. |
| title |
Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery |
| title_short |
Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery |
| title_full |
Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery |
| title_fullStr |
Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery |
| title_full_unstemmed |
Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery |
| title_sort |
neurodegenerative diseases in a dish: the promise of ipsc technology in disease modeling and therapeutic discovery |
| description |
The study of stem-cell biology has been a flourishing research area because of its multi-differentiation potential. The emergence of induced pluripotent stem cells (iPSCs) open up the possibility of addressing obstructs, such as the limited cell source, inherent complexity of the human brain, and ethical constrains. Though still at its infancy phase, reprogramming of somatic cells has been demonstrating the ability to enhance in vitro study of neurodegenerative diseases and potential treatment. However, iPSCs would not thoroughly translate to the clinic before limitations are addressed. In this review, by summarizing the recent development of iPSC-based models, we will discuss the feasibility of iPSC technology on relevant diseases depth and illustrate how this new tool applies to drug screening and celluar therapy. |
| publisher |
Springer Milan |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282683/ |
| _version_ |
1613172788733935616 |