Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

We tested the hypothesis that Lipofectamine siRNA delivery to deplete transient receptor potential cation channel (TRPC) 1 protein expression can suppress hypoxia-induced pulmonary arterial hypertension (PAH) in mice. Adult male C57BL/6 mice were equally divided into group 1 (normal controls), group...

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Bibliographic Details
Main Authors: Sun, Cheuk-Kwan, Zhen, Yen-Yi, Lu, Hung-I, Sung, Pei-Hsun, Chang, Li-Teh, Tsai, Tzu-Hsien, Sheu, Jiunn-Jye, Chen, Yung-Lung, Chua, Sarah, Chang, Hsueh-Wen, Chen, Yi-Ling, Lee, Fan-Yen, Yip, Hon-Kan
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281407/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281407/

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