Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling
The localization of ECSIT into the nucleus is specifically accompanied by p65/p50 NF-κB in a TLR4-dependent manner. p65 NF-κB specifically interacts with the ubiquitinated ECSIT on the Lys-372 residue, thereby regulating NF-κB activity, NF-κB–dependent gene expression, and production of proinflammat...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279226/ |