Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice

Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice

Cyclooxygenase type 2 (COX-2) plays a predominant role in the progression of kidney injury in obstructive nephropathy. The aim of this study was to test the efficacy of chitosan/small interfering RNA (siRNA) nanoparticles to knockdown COX-2 specifically in macrophages to prevent kidney injury induce...

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Bibliographic Details
Main Authors: Yang, Chuanxu, Nilsson, Line, Cheema, Muhammad Umar, Wang, Yan, Frøkiær, Jørgen, Gao, Shan, Kjems, Jørgen, Nørregaard, Rikke
Format: Online
Language:English
Published: Ivyspring International Publisher 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278998/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278998/

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