Decrease of Let-7f in Low-Dose Metronomic Paclitaxel Chemotherapy Contributed to Upregulation of Thrombospondin-1 in Breast Cancer

Low-dose metronomic (LDM) paclitaxel therapy displayed a stronger anti-angiogenic activity on breast tumors with fewer side effects. Upregulation of anti-angiogenic factor Thrombospondin-1 (TSP-1) accords for therapeutic potency of LDM paclitaxel, but its molecular mechanism has not been elucidated...

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Bibliographic Details
Main Authors: Tao, Wei-Yang, Liang, Xiao-Shuan, Liu, Yang, Wang, Chun-Yang, Pang, Da
Format: Online
Language:English
Published: Ivyspring International Publisher 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278254/