Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy

Autobiographical memory (AM) is understood as the retrieval of personal experiences that occurred in specific time and space. To date, there is no consensus on the role of medial temporal lobe structures in AM. Therefore, we investigated AM in medial temporal lobe epilepsy (TLE) patients. Twenty TLE...

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Main Authors:	Múnera, Claudia P., Lomlomdjian, Carolina, Gori, Belen, Terpiluk, Verónica, Medel, Nancy, Solís, Patricia, Kochen, Silvia
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274654/

id	pubmed-4274654
recordtype	oai_dc
spelling	pubmed-42746542014-12-29 Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy Múnera, Claudia P. Lomlomdjian, Carolina Gori, Belen Terpiluk, Verónica Medel, Nancy Solís, Patricia Kochen, Silvia Research Article Autobiographical memory (AM) is understood as the retrieval of personal experiences that occurred in specific time and space. To date, there is no consensus on the role of medial temporal lobe structures in AM. Therefore, we investigated AM in medial temporal lobe epilepsy (TLE) patients. Twenty TLE patients candidates for surgical treatment, 10 right (RTLE) and 10 left (LTLE), and 20 healthy controls were examined with a version of the Autobiographical Interview adapted to Spanish language. Episodic and semantic AM were analyzed during five life periods through two conditions: recall and specific probe. AM scores were compared with clinical and cognitive data. TLE patients showed lower performance in episodic AM than healthy controls, being significantly worst in RTLE group and after specific probe. In relation to semantic AM, LTLE retrieved higher amount of total semantic details compared to controls during recall, but not after specific probe. No significant differences were found between RTLE and LTLE, but a trend towards poorer performance in RTLE group was found. TLE patients obtained lower scores for adolescence period memories after specific probe. Our findings support the idea that the right hippocampus would play a more important role in episodic retrieval than the left, regardless of a temporal gradient. Hindawi Publishing Corporation 2014 2014-12-08 /pmc/articles/PMC4274654/ /pubmed/25548661 http://dx.doi.org/10.1155/2014/157452 Text en Copyright © 2014 Claudia P. Múnera et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Múnera, Claudia P. Lomlomdjian, Carolina Gori, Belen Terpiluk, Verónica Medel, Nancy Solís, Patricia Kochen, Silvia
spellingShingle	Múnera, Claudia P. Lomlomdjian, Carolina Gori, Belen Terpiluk, Verónica Medel, Nancy Solís, Patricia Kochen, Silvia Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy
author_facet	Múnera, Claudia P. Lomlomdjian, Carolina Gori, Belen Terpiluk, Verónica Medel, Nancy Solís, Patricia Kochen, Silvia
author_sort	Múnera, Claudia P.
title	Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy
title_short	Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy
title_full	Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy
title_fullStr	Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy
title_full_unstemmed	Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy
title_sort	episodic and semantic autobiographical memory in temporal lobe epilepsy
description	Autobiographical memory (AM) is understood as the retrieval of personal experiences that occurred in specific time and space. To date, there is no consensus on the role of medial temporal lobe structures in AM. Therefore, we investigated AM in medial temporal lobe epilepsy (TLE) patients. Twenty TLE patients candidates for surgical treatment, 10 right (RTLE) and 10 left (LTLE), and 20 healthy controls were examined with a version of the Autobiographical Interview adapted to Spanish language. Episodic and semantic AM were analyzed during five life periods through two conditions: recall and specific probe. AM scores were compared with clinical and cognitive data. TLE patients showed lower performance in episodic AM than healthy controls, being significantly worst in RTLE group and after specific probe. In relation to semantic AM, LTLE retrieved higher amount of total semantic details compared to controls during recall, but not after specific probe. No significant differences were found between RTLE and LTLE, but a trend towards poorer performance in RTLE group was found. TLE patients obtained lower scores for adolescence period memories after specific probe. Our findings support the idea that the right hippocampus would play a more important role in episodic retrieval than the left, regardless of a temporal gradient.
publisher	Hindawi Publishing Corporation
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274654/
_version_	1613170023907459072

Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy

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