An Improved Model for the hTERT Promoter Quadruplex

Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadrupl...

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Main Authors:	Chaires, Jonathan B., Trent, John O., Gray, Robert D., Dean, William L., Buscaglia, Robert, Thomas, Shelia D., Miller, Donald M.
Format:	Online
Language:	English
Published:	Public Library of Science 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272262/

id	pubmed-4272262
recordtype	oai_dc
spelling	pubmed-42722622014-12-26 An Improved Model for the hTERT Promoter Quadruplex Chaires, Jonathan B. Trent, John O. Gray, Robert D. Dean, William L. Buscaglia, Robert Thomas, Shelia D. Miller, Donald M. Research Article Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadruplex structure consisting of three contiguous, stacked parallel quadruplexes. The reported hTERT mutations map to the central quadruplex within this structure, and lead to an alteration of its hydrodynamic properties and stability. Public Library of Science 2014-12-19 /pmc/articles/PMC4272262/ /pubmed/25526084 http://dx.doi.org/10.1371/journal.pone.0115580 Text en © 2014 Chaires et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chaires, Jonathan B. Trent, John O. Gray, Robert D. Dean, William L. Buscaglia, Robert Thomas, Shelia D. Miller, Donald M.
spellingShingle	Chaires, Jonathan B. Trent, John O. Gray, Robert D. Dean, William L. Buscaglia, Robert Thomas, Shelia D. Miller, Donald M. An Improved Model for the hTERT Promoter Quadruplex
author_facet	Chaires, Jonathan B. Trent, John O. Gray, Robert D. Dean, William L. Buscaglia, Robert Thomas, Shelia D. Miller, Donald M.
author_sort	Chaires, Jonathan B.
title	An Improved Model for the hTERT Promoter Quadruplex
title_short	An Improved Model for the hTERT Promoter Quadruplex
title_full	An Improved Model for the hTERT Promoter Quadruplex
title_fullStr	An Improved Model for the hTERT Promoter Quadruplex
title_full_unstemmed	An Improved Model for the hTERT Promoter Quadruplex
title_sort	improved model for the htert promoter quadruplex
description	Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadruplex structure consisting of three contiguous, stacked parallel quadruplexes. The reported hTERT mutations map to the central quadruplex within this structure, and lead to an alteration of its hydrodynamic properties and stability.
publisher	Public Library of Science
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272262/
_version_	1613169265627627520

An Improved Model for the hTERT Promoter Quadruplex

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