Anthelmintic effect of carob pods and sainfoin hay when fed to lambs after experimental trickle infections with Haemonchus contortus and Trichostrongylus colubriformis

The aim of the study was to compare the in vivo anthelmintic activity of sainfoin hay (Onobrychis viciifolia) and carob pod meal (Ceratonia siliqua) against gastrointestinal nematodes. Seven days before infection, 64 naive lambs were assigned to four different groups: Group S received sainfoin hay a...

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Main Authors:	Arroyo-Lopez, Celia, Manolaraki, Foteini, Saratsis, Anastasios, Saratsi, Katerina, Stefanakis, Alexandros, Skampardonis, Vasileios, Voutzourakis, Nikolaos, Hoste, Hervé, Sotiraki, Smaragda
Format:	Online
Language:	English
Published:	EDP Sciences 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271655/

id	pubmed-4271655
recordtype	oai_dc
spelling	pubmed-42716552014-12-29 Anthelmintic effect of carob pods and sainfoin hay when fed to lambs after experimental trickle infections with Haemonchus contortus and Trichostrongylus colubriformis Arroyo-Lopez, Celia Manolaraki, Foteini Saratsis, Anastasios Saratsi, Katerina Stefanakis, Alexandros Skampardonis, Vasileios Voutzourakis, Nikolaos Hoste, Hervé Sotiraki, Smaragda Research Article The aim of the study was to compare the in vivo anthelmintic activity of sainfoin hay (Onobrychis viciifolia) and carob pod meal (Ceratonia siliqua) against gastrointestinal nematodes. Seven days before infection, 64 naive lambs were assigned to four different groups: Group S received sainfoin hay and group CAR was fed with carob pods. The remaining lambs received lucerne hay (Medicago sativa) and were assigned to positive (non-treated, NT) and negative (treated, T) control groups (treatment with albendazole). On day 0, lambs were artificially trickle infected for 6 weeks, with a mixture of infective larvae of Haemonchus contortus and Trichostrongylus colubriformis. Parasitological and pathophysiological parameters were measured repeatedly during the 2-month study. Compared to the NT group, decreases in egg excretion were observed in the CAR and S groups with significant differences only found for sainfoin (p < 0.05). At necropsy, group S showed decreases in the total worm numbers of both nematode species with significant differences for H. contortus. In contrast, no differences were noticed for the CAR group. Compared to the NT group, lower values for fecundity of female H. contortus were found in the S and CAR groups, however differences were non-significant. No differences in body weight gains were found between groups. Consistent results were found showing significantly higher packed cell volume (PCV) values in the T and S groups compared to NT and CAR groups. Overall, these results confirm a positive effect associated with the feeding of lambs with tanniniferous resources on host resilience (PCV values) and against gastrointestinal parasitic nematodes by affecting some biological traits of worm populations (e.g. eggs per gram of faeces and worm numbers). However, the anthelmintic effects differed between the two tannin-containing resources, which might be associated with the quantity and/or quality of secondary metabolites (condensed tannins and/or other polyphenols). EDP Sciences 2014 2014-12-22 /pmc/articles/PMC4271655/ /pubmed/25526546 http://dx.doi.org/10.1051/parasite/2014074 Text en © C. Arroyo-Lopez et al., published by EDP Sciences, 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Arroyo-Lopez, Celia Manolaraki, Foteini Saratsis, Anastasios Saratsi, Katerina Stefanakis, Alexandros Skampardonis, Vasileios Voutzourakis, Nikolaos Hoste, Hervé Sotiraki, Smaragda
spellingShingle	Arroyo-Lopez, Celia Manolaraki, Foteini Saratsis, Anastasios Saratsi, Katerina Stefanakis, Alexandros Skampardonis, Vasileios Voutzourakis, Nikolaos Hoste, Hervé Sotiraki, Smaragda Anthelmintic effect of carob pods and sainfoin hay when fed to lambs after experimental trickle infections with Haemonchus contortus and Trichostrongylus colubriformis
author_facet	Arroyo-Lopez, Celia Manolaraki, Foteini Saratsis, Anastasios Saratsi, Katerina Stefanakis, Alexandros Skampardonis, Vasileios Voutzourakis, Nikolaos Hoste, Hervé Sotiraki, Smaragda
author_sort	Arroyo-Lopez, Celia
title	Anthelmintic effect of carob pods and sainfoin hay when fed to lambs after experimental trickle infections with Haemonchus contortus and Trichostrongylus colubriformis
title_short	Anthelmintic effect of carob pods and sainfoin hay when fed to lambs after experimental trickle infections with Haemonchus contortus and Trichostrongylus colubriformis
title_full	Anthelmintic effect of carob pods and sainfoin hay when fed to lambs after experimental trickle infections with Haemonchus contortus and Trichostrongylus colubriformis
title_fullStr	Anthelmintic effect of carob pods and sainfoin hay when fed to lambs after experimental trickle infections with Haemonchus contortus and Trichostrongylus colubriformis
title_full_unstemmed	Anthelmintic effect of carob pods and sainfoin hay when fed to lambs after experimental trickle infections with Haemonchus contortus and Trichostrongylus colubriformis
title_sort	anthelmintic effect of carob pods and sainfoin hay when fed to lambs after experimental trickle infections with haemonchus contortus and trichostrongylus colubriformis
description	The aim of the study was to compare the in vivo anthelmintic activity of sainfoin hay (Onobrychis viciifolia) and carob pod meal (Ceratonia siliqua) against gastrointestinal nematodes. Seven days before infection, 64 naive lambs were assigned to four different groups: Group S received sainfoin hay and group CAR was fed with carob pods. The remaining lambs received lucerne hay (Medicago sativa) and were assigned to positive (non-treated, NT) and negative (treated, T) control groups (treatment with albendazole). On day 0, lambs were artificially trickle infected for 6 weeks, with a mixture of infective larvae of Haemonchus contortus and Trichostrongylus colubriformis. Parasitological and pathophysiological parameters were measured repeatedly during the 2-month study. Compared to the NT group, decreases in egg excretion were observed in the CAR and S groups with significant differences only found for sainfoin (p < 0.05). At necropsy, group S showed decreases in the total worm numbers of both nematode species with significant differences for H. contortus. In contrast, no differences were noticed for the CAR group. Compared to the NT group, lower values for fecundity of female H. contortus were found in the S and CAR groups, however differences were non-significant. No differences in body weight gains were found between groups. Consistent results were found showing significantly higher packed cell volume (PCV) values in the T and S groups compared to NT and CAR groups. Overall, these results confirm a positive effect associated with the feeding of lambs with tanniniferous resources on host resilience (PCV values) and against gastrointestinal parasitic nematodes by affecting some biological traits of worm populations (e.g. eggs per gram of faeces and worm numbers). However, the anthelmintic effects differed between the two tannin-containing resources, which might be associated with the quantity and/or quality of secondary metabolites (condensed tannins and/or other polyphenols).
publisher	EDP Sciences
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271655/
_version_	1613169155266052096

Anthelmintic effect of carob pods and sainfoin hay when fed to lambs after experimental trickle infections with Haemonchus contortus and Trichostrongylus colubriformis

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