Modelling the contribution of the hypnozoite reservoir to Plasmodium vivax transmission

Plasmodium vivax relapse infections occur following activation of latent liver-stages parasites (hypnozoites) causing new blood-stage infections weeks to months after the initial infection. We develop a within-host mathematical model of liver-stage hypnozoites, and validate it against data from trop...

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Bibliographic Details
Main Authors: White, Michael T, Karl, Stephan, Battle, Katherine E, Hay, Simon I, Mueller, Ivo, Ghani, Azra C
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270097/