Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1

Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1

Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1)...

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Bibliographic Details
Main Authors: Fusi, Camilla, Materazzi, Serena, Benemei, Silvia, Coppi, Elisabetta, Trevisan, Gabriela, Marone, Ilaria M., Minocci, Daiana, De Logu, Francesco, Tuccinardi, Tiziano, Di Tommaso, Maria Rosaria, Susini, Tommaso, Moneti, Gloriano, Pieraccini, Giuseppe, Geppetti, Pierangelo, Nassini, Romina
Format: Online
Language:English
Published: Nature Pub. Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268712/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268712/

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