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Constrained transcription factor spacing is prevalent and important for transcriptional control of mouse blood cells

Combinatorial transcription factor (TF) binding is essential for cell-type-specific gene regulation. However, much remains to be learned about the mechanisms of TF interactions, including to what extent constrained spacing and orientation of interacting TFs are critical for regulatory element activi...

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Bibliographic Details
Main Authors: Ng, Felicia SL, Schütte, Judith, Ruau, David, Diamanti, Evangelia, Hannah, Rebecca, Kinston, Sarah J., Göttgens, Berthold
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267662/