Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma

Gain-of-function CCR4 mutations in adult T cell leukemia/lymphoma

Adult T cell leukemia/lymphoma (ATLL) is an aggressive malignancy without a cure. Louis Staudt and colleagues identified gain-of-function mutations in the chemokine receptor CCR4 in ATLL patient samples. The mutations increased cell migration and conferred a growth advantage in ATLL cells. The findi...

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Bibliographic Details
Main Authors: Nakagawa, Masao, Schmitz, Roland, Xiao, Wenming, Goldman, Carolyn K., Xu, Weihong, Yang, Yandan, Yu, Xin, Waldmann, Thomas A., Staudt, Louis M.
Format: Online
Language:English
Published: The Rockefeller University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267233/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267233/

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