The Antipsychotic Olanzapine Interacts with the Gut Microbiome to Cause Weight Gain in Mouse

The Antipsychotic Olanzapine Interacts with the Gut Microbiome to Cause Weight Gain in Mouse

The second-generation antipsychotic olanzapine is effective in reducing psychotic symptoms but can cause extreme weight gain in human patients. We investigated the role of the gut microbiota in this adverse drug effect using a mouse model. First, we used germ-free C57BL/6J mice to demonstrate that g...

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Bibliographic Details
Main Authors: Morgan, Andrew P., Crowley, James J., Nonneman, Randal J., Quackenbush, Corey R., Miller, Cheryl N., Ryan, Allison K., Bogue, Molly A., Paredes, Sur Herrera, Yourstone, Scott, Carroll, Ian M., Kawula, Thomas H., Bower, Maureen A., Sartor, R. Balfour, Sullivan, Patrick F.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266663/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266663/

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