TLR Cross-talk Confers Specificity to Innate Immunity

Cross-talk within the innate immune pathways is highly complex and contains many unknowns. Here, we discuss the different combinations of PAMPs, together with the sequence, order, and dosage of consecutive PAMP challenges, which determine the nature of the immune response by macrophages. The engagem...

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Main Authors:	Tan, Rebecca S. T., Ho, Bow, Leung, Bernard P., Ding, Jeak L.
Format:	Online
Language:	English
Published:	Informa Healthcare 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266099/

id	pubmed-4266099
recordtype	oai_dc
spelling	pubmed-42660992014-12-29 TLR Cross-talk Confers Specificity to Innate Immunity Tan, Rebecca S. T. Ho, Bow Leung, Bernard P. Ding, Jeak L. Review Cross-talk within the innate immune pathways is highly complex and contains many unknowns. Here, we discuss the different combinations of PAMPs, together with the sequence, order, and dosage of consecutive PAMP challenges, which determine the nature of the immune response by macrophages. The engagement of different Toll-like receptor (TLR) ligands leads to quantitatively and qualitatively unique cytokine production, showing that TLR pathway crosstalk enables the innate immune system to orchestrate immediate local and global responses. It is likely that multiple pathways are involved in the regulation of cytokine synergy, including many that have yet to be discovered. Informa Healthcare 2014-11 2014-06-09 /pmc/articles/PMC4266099/ /pubmed/24911430 http://dx.doi.org/10.3109/08830185.2014.921164 Text en © 2014 Informa Healthcare USA, Inc. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the CC-BY-NC-ND 3.0 License which permits users to download and share the article for non-commercial purposes, so long as the article is reproduced in the whole without changes, and provided the original source is credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tan, Rebecca S. T. Ho, Bow Leung, Bernard P. Ding, Jeak L.
spellingShingle	Tan, Rebecca S. T. Ho, Bow Leung, Bernard P. Ding, Jeak L. TLR Cross-talk Confers Specificity to Innate Immunity
author_facet	Tan, Rebecca S. T. Ho, Bow Leung, Bernard P. Ding, Jeak L.
author_sort	Tan, Rebecca S. T.
title	TLR Cross-talk Confers Specificity to Innate Immunity
title_short	TLR Cross-talk Confers Specificity to Innate Immunity
title_full	TLR Cross-talk Confers Specificity to Innate Immunity
title_fullStr	TLR Cross-talk Confers Specificity to Innate Immunity
title_full_unstemmed	TLR Cross-talk Confers Specificity to Innate Immunity
title_sort	tlr cross-talk confers specificity to innate immunity
description	Cross-talk within the innate immune pathways is highly complex and contains many unknowns. Here, we discuss the different combinations of PAMPs, together with the sequence, order, and dosage of consecutive PAMP challenges, which determine the nature of the immune response by macrophages. The engagement of different Toll-like receptor (TLR) ligands leads to quantitatively and qualitatively unique cytokine production, showing that TLR pathway crosstalk enables the innate immune system to orchestrate immediate local and global responses. It is likely that multiple pathways are involved in the regulation of cytokine synergy, including many that have yet to be discovered.
publisher	Informa Healthcare
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266099/
_version_	1613167541836840960

TLR Cross-talk Confers Specificity to Innate Immunity

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