Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin-1

Upregulated periostin promotes angiogenesis in keloids through activation of the ERK 1/2 and focal adhesion kinase pathways, as well as the upregulated expression of VEGF and angiopoietin-1

Periostin, a secreted extracellular matrix protein, is highly expressed in wound healing and in various types of human cancer and is involved in angiogenesis. Keloids, considered dermal benign tumors, are granulomatous lesions characterized by capillary proliferation. However, the underlying regulat...

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Bibliographic Details
Main Authors: ZHANG, ZHE, NIE, FANGFEI, CHEN, XINLEI, QIN, ZELIAN, KANG, CHUNFU, CHEN, BIN, MA, JIANXUN, PAN, BOLIN, MA, YONGGUANG
Format: Online
Language:English
Published: D.A. Spandidos 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262479/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262479/

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