Liquid biopsy in gastrointestinal stromal tumors: a novel approach

The role of molecular analysis in the management of gastrointestinal stromal tumors (GIST) remains indisputable. To date, tumor tissue extracted from specimens obtained by surgical or biopsy procedures has been the only source of the tumor DNA required for the molecular and genomic assessment of can...

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Main Authors:	Nannini, Margherita, Astolfi, Annalisa, Urbini, Milena, Biasco, Guido, Pantaleo, Maria A
Format:	Online
Language:	English
Published:	BioMed Central 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262092/

id	pubmed-4262092
recordtype	oai_dc
spelling	pubmed-42620922014-12-11 Liquid biopsy in gastrointestinal stromal tumors: a novel approach Nannini, Margherita Astolfi, Annalisa Urbini, Milena Biasco, Guido Pantaleo, Maria A Commentary The role of molecular analysis in the management of gastrointestinal stromal tumors (GIST) remains indisputable. To date, tumor tissue extracted from specimens obtained by surgical or biopsy procedures has been the only source of the tumor DNA required for the molecular and genomic assessment of cancer. However, tumor tissue sampling has several clinical limitations: for example, the invasiveness of these procedures precludes repeated sampling. Thus, it is possible to obtain only a static molecular picture of the disease, a picture that lacks the inter- and intra-metastatic molecular heterogeneity that characterizes most GIST. In contrast, circulating tumor DNA obtained from a patient’s bloodstream, known as liquid biopsy, can theoretically overcome the limitations of tissue biopsies and provide the same molecular and genomic information. GIST are recognized as a paradigm of molecular biology among solid tumors. Although few but promising data on liquid biopsy in GIST have been accumulated to date, these tumors may provide the optimal field for application of this challenging approach. BioMed Central 2014-08-14 /pmc/articles/PMC4262092/ /pubmed/25123679 http://dx.doi.org/10.1186/1479-5876-12-210 Text en © Nannini et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Nannini, Margherita Astolfi, Annalisa Urbini, Milena Biasco, Guido Pantaleo, Maria A
spellingShingle	Nannini, Margherita Astolfi, Annalisa Urbini, Milena Biasco, Guido Pantaleo, Maria A Liquid biopsy in gastrointestinal stromal tumors: a novel approach
author_facet	Nannini, Margherita Astolfi, Annalisa Urbini, Milena Biasco, Guido Pantaleo, Maria A
author_sort	Nannini, Margherita
title	Liquid biopsy in gastrointestinal stromal tumors: a novel approach
title_short	Liquid biopsy in gastrointestinal stromal tumors: a novel approach
title_full	Liquid biopsy in gastrointestinal stromal tumors: a novel approach
title_fullStr	Liquid biopsy in gastrointestinal stromal tumors: a novel approach
title_full_unstemmed	Liquid biopsy in gastrointestinal stromal tumors: a novel approach
title_sort	liquid biopsy in gastrointestinal stromal tumors: a novel approach
description	The role of molecular analysis in the management of gastrointestinal stromal tumors (GIST) remains indisputable. To date, tumor tissue extracted from specimens obtained by surgical or biopsy procedures has been the only source of the tumor DNA required for the molecular and genomic assessment of cancer. However, tumor tissue sampling has several clinical limitations: for example, the invasiveness of these procedures precludes repeated sampling. Thus, it is possible to obtain only a static molecular picture of the disease, a picture that lacks the inter- and intra-metastatic molecular heterogeneity that characterizes most GIST. In contrast, circulating tumor DNA obtained from a patient’s bloodstream, known as liquid biopsy, can theoretically overcome the limitations of tissue biopsies and provide the same molecular and genomic information. GIST are recognized as a paradigm of molecular biology among solid tumors. Although few but promising data on liquid biopsy in GIST have been accumulated to date, these tumors may provide the optimal field for application of this challenging approach.
publisher	BioMed Central
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262092/
_version_	1613166106690715648

Liquid biopsy in gastrointestinal stromal tumors: a novel approach

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