Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells

Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells

In this study, we investigate whether arsenite-induced DNA damage leads to p53-dependent premature senescence using human glioblastoma cells with p53-wild type (U87MG-neo) and p53 deficient (U87MG-E6). A dose dependent relationship between arsenite and reduced cell growth is demonstrated, as well as...

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Bibliographic Details
Main Authors: Ninomiya, Yasuharu, Cui, Xing, Yasuda, Takeshi, Wang, Bing, Yu, Dong, Sekine-Suzuki, Emiko, Nenoi, Mitsuru
Format: Online
Language:English
Published: Korean Society for Biochemistry and Molecular Biology 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261516/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261516/

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