Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes
We recently reported that genetic deletion of myeloperoxidase (MPO) alleviates obesity-related insulin resistance in mice in vivo. How MPO impairs insulin sensitivity in adipocytes is poorly characterized. As hypochlorous acid (HOCl) is a principal oxidant product generated by MPO, we evaluated the...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Bioscientifica Ltd
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261204/ |