SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis

SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis

In skeletogenic mesenchyme, SOXC proteins enter the APC–Axin destruction complex to inhibit β-catenin phosphorylation by GSK3 and thereby synergize with canonical WNT signaling to inhibit chondrogenesis.

Bibliographic Details
Main Authors: Bhattaram, Pallavi, Penzo-Méndez, Alfredo, Kato, Kenji, Bandyopadhyay, Kaustav, Gadi, Abhilash, Taketo, Makoto M., Lefebvre, Véronique
Format: Online
Language:English
Published: The Rockefeller University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259807/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259807/

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