Identification of a neural crest rudiment in a non-vertebrate chordate
Neural crest arises at the neural plate border, expresses a core set of regulatory genes, and produces a diverse array of cell types including ectomesenchyme derivatives that elaborate the vertebrate head1,2. The evolution of neural crest has been postulated as a key event leading to the appearance...
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2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257486/ |
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pubmed-4257486 |
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pubmed-42574862014-12-05 Identification of a neural crest rudiment in a non-vertebrate chordate Abitua, Philip Barron Wagner, Eileen Navarrete, Ignacio A. Levine, Michael Article Neural crest arises at the neural plate border, expresses a core set of regulatory genes, and produces a diverse array of cell types including ectomesenchyme derivatives that elaborate the vertebrate head1,2. The evolution of neural crest has been postulated as a key event leading to the appearance of new cell types that fostered the transition from filter feeding to active predation in ancestral vertebrates3. However, the origin of neural crest remains controversial, since homologous cell types have not been unambiguously identified in non-vertebrate chordates1,4. Here we show that the tunicate Ciona intestinalis possesses a cephalic melanocyte lineage (a9.49) similar to neural crest that can be reprogrammed into migrating ectomesenchyme by the targeted misexpression of Twist. Our results suggest that the neural crest melanocyte regulatory network predated the divergence of tunicates and vertebrates. We propose that the co-option of mesenchyme determinants, such as Twist, into the neural plate ectoderm was crucial for the emergence of the vertebrate “new head”3. 2012-11-07 2012-12-06 /pmc/articles/PMC4257486/ /pubmed/23135395 http://dx.doi.org/10.1038/nature11589 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Abitua, Philip Barron Wagner, Eileen Navarrete, Ignacio A. Levine, Michael |
| spellingShingle |
Abitua, Philip Barron Wagner, Eileen Navarrete, Ignacio A. Levine, Michael Identification of a neural crest rudiment in a non-vertebrate chordate |
| author_facet |
Abitua, Philip Barron Wagner, Eileen Navarrete, Ignacio A. Levine, Michael |
| author_sort |
Abitua, Philip Barron |
| title |
Identification of a neural crest rudiment in a non-vertebrate chordate |
| title_short |
Identification of a neural crest rudiment in a non-vertebrate chordate |
| title_full |
Identification of a neural crest rudiment in a non-vertebrate chordate |
| title_fullStr |
Identification of a neural crest rudiment in a non-vertebrate chordate |
| title_full_unstemmed |
Identification of a neural crest rudiment in a non-vertebrate chordate |
| title_sort |
identification of a neural crest rudiment in a non-vertebrate chordate |
| description |
Neural crest arises at the neural plate border, expresses a core set of regulatory genes, and produces a diverse array of cell types including ectomesenchyme derivatives that elaborate the vertebrate head1,2. The evolution of neural crest has been postulated as a key event leading to the appearance of new cell types that fostered the transition from filter feeding to active predation in ancestral vertebrates3. However, the origin of neural crest remains controversial, since homologous cell types have not been unambiguously identified in non-vertebrate chordates1,4. Here we show that the tunicate Ciona intestinalis possesses a cephalic melanocyte lineage (a9.49) similar to neural crest that can be reprogrammed into migrating ectomesenchyme by the targeted misexpression of Twist. Our results suggest that the neural crest melanocyte regulatory network predated the divergence of tunicates and vertebrates. We propose that the co-option of mesenchyme determinants, such as Twist, into the neural plate ectoderm was crucial for the emergence of the vertebrate “new head”3. |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257486/ |
| _version_ |
1613164619784781824 |