Loss of Tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy
Nemaline myopathy is an inherited muscle disease that is mainly diagnosed by the presence of nemaline rods in muscle biopsies. Of the nine genes associated with the disease, five encode components of striated muscle sarcomeres. In a genetic zebrafish screen, the mutant träge (trg) was isolated based...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Company of Biologists Limited
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257009/ |