A Novel and Fast Approach for Population Structure Inference Using Kernel-PCA and Optimization
Population structure is a confounding factor in genome-wide association studies, increasing the rate of false positive associations. To correct for it, several model-based algorithms such as ADMIXTURE and STRUCTURE have been proposed. These tend to suffer from the fact that they have a considerable...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Genetics Society of America
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256762/ |