Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC

Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC

In head and neck squamous cell cancer (HNSCC), four intrinsic subtypes (or groups) have been identified, and each one possesses a unique biology that will require specific treatment strategies. We previously reported that mesenchymal (group 2) tumors exhibit reduced levels of Trop2 expression. In th...

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Bibliographic Details
Main Authors: Zhang, Kaihua, Jones, Lamont, Lim, Sora, Maher, Christopher A., Adkins, Douglas, Lewis, James, Kimple, Randall J., Fertig, Elana J., Chung, Christine H., Herrlich, Andreas, Ellis, Matthew J., Van Tine, Brian A., Michel, Loren S.
Format: Online
Language:English
Published: Impact Journals LLC 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253434/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253434/

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